Author(s): Alice Jaillard, Grégory Petyt, Maxime Morelle, Caroline Moreau and Franck Semah
Hypometabolism in the fronto-mesial cortex and in the anterior cingulate cortex were reported in patients with progressive supranuclear palsy (PSP). Severe neuronal loss, associated with gliosis and neurofibrillary tangles were reported in the superior colliculi of patients with PSP in the initial clinico-neuropathological description of the disease by Steele, Richardson and Olszewski. Nowadays, high-resolution positron emission tomography with [fluorine-18] fluoro-D-glucose (18F-FDG PET) with magnetic resonance (MR) image fusion can reveal hypometabolism in the superior colliculi in patients with PSP.
