Author(s): Sherif Salah
Introduction: Multiple sclerosis (MS) is a complex inflammatory demyelinating disease of the central nervous system (CNS) with both genetic and environmental contributing factors. In recent years, increasing evidence has pointed to the potential role of fibrinolysis in the pathogenesis of MS. Based on hypotheses describing the aggressive autoimmune responses observed in MS patients, a result of impaired which results in impairment between t-PA and PA1-1 which are a key molecules in both fibrinolysis and extracellular proteolysis.
Aim of the study: The aim of the present study is to investigate the therapeutic potential of polymerase enzyme in modulating the changes occurring between levels of Tissue- type plasminogen activator (t-PA) and its inhibitor (PAI-1) in patients with multiple sclerosis.
Patients and methods: A pilot study was carried out on a total of twenty-one patients (17 females, 4 males; aged 22-46 years) with demyelination suggestive of MS and clinically silent T2 brain lesions on magnetic resonance imaging (MRI). All of the examined patients showed the same clinical symptoms of MS and consented to take the novel therapy in the form of subcutaneous injection of 0.1 cc of DNA polymerase enzyme twice daily for 24 weeks. At the beginning of this study and at the end of therapy the plasmatic levels of PAI-1and t-PA were measured by ELISA and their values were expressed in ng/mg of protein.
Results: All patients showed a significant association between the decreased levels of PAI-1and the disappearance of annualized relapse rate (ARR), disability progression, and magnetic resonance imaging (MRI) activity.
Conclusion: From this study we conclude that DNA polymerase is viable therapeutic option in patients with MS.
